Position Summary

The laboratories of Dr. Jeff Milbrandt and Dr. Rob Mitra invite highly motivated candidates to apply for positions as joint postdoctoral fellows in the Department of Genetics and McDonnell Genome Institute at WashU in St. Louis. These fellows will develop research programs in Personalized Medicine aimed at revealing the pathogenic mechanisms of disease-associated variants via monitoring phenotypic changes of genetically perturbed iPSC-derived neurons and glia.

Our collaborative, multidisciplinary group studies the mechanistic basis of genetic abnormalities that result in neurodevelopmental, neuropsychiatric, or neurodegenerative disorders, with particular emphasis on the role of mitochondrial dysfunction and metabolic deficits in disease progression. To address these questions, we use a novel multi-omics approach that integrates high-throughput imaging and machine learning methods with CRISPR/Cas9 screens and saturation mutagenesis to answer central questions about the pathophysiology that results from genetic mutations in mitochondrial proteins, chromatin regulators, and metabolic enzymes. We interpret our experiments in the context of curated clinical phenotypes and validate key findings using banked patient samples.

This opportunity requires the ability to visit St. Louis for potential interviews.

Job Description

Primary Duties & Responsibilities:

Information on being a postdoc at WashU in St. Louis can be found at https://postdoc.wustl.edu/prospective-postdocs-2/.

For more information on the lab please visit https://milbrandtlab.wustl.edu/.

Working Conditions:

This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary Range:

Base pay is commensurate with experience.

Applicant Special Instructions:

To apply for this position, applicants should email a single PDF file consisting of a letter of interest, CV, and arrange for three letters of reference to be sent to Dr. Jeff Milbrandt and Dr. Rob Mitra at MorphNSort@genetics.wustl.edu.

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Required Qualifications

Education:

Ph.D., M.D. Or Equivalent Terminal Or Doctoral Degree.

Certifications/Professional Licenses:

No specific certification/professional license is required for this position.

Work Experience:

No specific work experience is required for this position.

Skills:

Not Applicable

Driver's License:

A driver's license is not required for this position.

Preferred Qualifications

• Ph.D. or M.D./Ph.D. in biological sciences or related fields.

Skills:

Analytical Thinking, Communication, Genomics, Molecular Biology, Neurodegenerative Diseases, Python (Programming Language), R Programming