Overview of the Landmark Cureus Study on Preterm Infants Survival in UAE
A groundbreaking retrospective cohort study published on February 16, 2026, in Cureus journal sheds new light on survival rates and short-term outcomes for preterm infants born before 32 weeks gestational age at a leading tertiary medical center in the United Arab Emirates. Titled "Trends in Survival and Short-Term Outcomes Among Preterm Infants Less Than 32 Weeks From 2016 to 2022," the research draws from data at Tawam Hospital in Al Ain, revealing an overall survival rate of 79% among 700 infants, with notable improvements over the study period. This publication, led by neonatologists including Mustafa Alabdullatif from the College of Medicine and Health Sciences (CMHS) at United Arab Emirates University (UAEU), underscores the UAE's strides in neonatal intensive care unit (NICU) capabilities while highlighting persistent challenges in managing morbidities.
Preterm birth, defined as delivery before 37 weeks of gestation, remains a leading cause of neonatal mortality and morbidity worldwide. In the UAE, where advanced healthcare infrastructure meets a diverse expatriate population, such localized data is crucial for tailoring interventions. The study's findings offer evidence-based insights for clinicians, policymakers, and families navigating high-risk pregnancies.
Preterm Birth Landscape in the United Arab Emirates
The UAE reports preterm birth rates around 6-12%, influenced by factors like high rates of in vitro fertilization (IVF) pregnancies—39% in the study cohort—and multiple births at 45.2%. Emirati infants comprised 82% of cases, reflecting national demographics amid a population boom. Risk factors include maternal conditions such as premature rupture of membranes (PROM, 27%), gestational diabetes (29%), and hypertension (15%), with antenatal corticosteroid use rising from 78% in 2016 to 87% in 2022, signaling better prenatal protocols.
Tertiary centers like Tawam Hospital, a 503-bed facility with a 51-bed Level III NICU, play pivotal roles. Affiliated with UAEU CMHS, it serves as a teaching hub, integrating clinical care, education, and research. This synergy exemplifies how UAE higher education institutions drive neonatal advancements.
Methodology: A Robust Retrospective Analysis
Researchers analyzed 700 inborn infants (22+0 to 31+6 weeks GA) admitted to Tawam Hospital NICU from 2016-2022, excluding outborns, congenital anomalies, or chromosomal issues. Data encompassed demographics, maternal history, resuscitation, and outcomes using standardized definitions (e.g., Jensen for bronchopulmonary dysplasia [BPD], Papile for intraventricular hemorrhage [IVH]). Periods were split: 2016-2019 (n=387) vs. 2020-2022 (n=313) to detect temporal shifts.
Statistical rigor included chi-square tests and ANOVA, with p<0.05 significance. Median gestational age was 27 weeks, birth weight 1113g, highlighting a very preterm-heavy cohort.
Survival Rates: Impressive Gains Especially in Extreme Preterms
Overall, 553 infants (79%) survived to discharge, with median NICU stay of 67 days for survivors. Mortality dropped significantly from 23.8% (92/387) in period 1 to 17.6% (55/313) in period 2 (p=0.045). For extreme preterms (<28 weeks), survival rose from 51.3% to 63.9% (p=0.031).
- 22 weeks: 0% survival (100% mortality)
- 23 weeks: 13% survival
- 24 weeks: 56.4% survival
- 25-27 weeks: 78-92.5% survival
- 28-31 weeks: >90% survival
These trends mirror global improvements but lag slightly behind networks like the Canadian Neonatal Network (CNN), attributed to higher-risk profiles (e.g., multiples).Read the full Cureus study
Short-Term Morbidities: The Trade-Off with Survival
Survival gains coincided with rising morbidities, emphasizing quality-of-life concerns. BPD affected 40.5% (228/563), surging from 33.8% to 48.1% (p<0.0001). Late-onset sepsis hit 30.1%, up from 25.5% to 35.6% (p=0.005). Periventricular leukomalacia (PVL) doubled to 11.2% (p=0.038).
| Morbidity | Overall Rate | Period 1 | Period 2 | p-value |
|---|---|---|---|---|
| BPD (any) | 40.5% | 33.8% | 48.1% | <0.0001 |
| Late-onset Sepsis | 30.1% | 25.5% | 35.6% | 0.005 |
| IVH ≥3 | 9.2% | 10.1% | 8.0% | 0.357 |
| NEC ≥2 | 12.9% | 11.8% | 14.3% | 0.327 |
| ROP Treatment | 8.5% | 7.1% | 10.0% | 0.239 |
| PDA Treatment | 16.7% | 13.6% | 20.6% | 0.015 |
Neurological injuries like severe IVH (9.2%) showed non-significant decline. Interventions: PDA ligation/closure 16.7%, ROP laser 8.5%.
Photo by Brett Jordan on Unsplash
International and Regional Comparisons
Tawam's outcomes compare variably: mortality 21% vs. CNN 7%, ANZNN 8%; BPD 40.5% vs. 21-38%; sepsis 30.1% vs. 9-23%. Higher local rates link to 45% multiples vs. 25-30% elsewhere, and inclusive GA cohorts. Prior UAE data (e.g., 2011 Al Ain study) showed lower survival, marking progress. Saudi centers report similar challenges, positioning UAE as regional leader.
Related periviable study from TawamDrivers of Improvement: Antenatal Steroids and Magnesium Sulfate
Antenatal corticosteroids reached 87%, magnesium sulfate for neuroprotection 53%, correlating with survival upticks. Resuscitation advanced: intubation rates declined, CPAP increased. These align with UAE Ministry of Health guidelines, bolstered by higher ed training programs at UAEU CMHS.
- Increased antenatal steroids: Reduced respiratory distress
- MgSO4 uptake: Lowered cerebral palsy risk
- High IVF monitoring: Proactive multiple birth management
For aspiring neonatologists, explore clinical research jobs in UAE universities.
UAE Higher Education's Role in Neonatal Research Excellence
Tawam Hospital's UAEU affiliation exemplifies public-private-academic synergy. CMHS faculty like co-author Alabdullatif contribute to publications, training residents in evidence-based care. UAE's research surge—e.g., MBZUAI AI grants—extends to health sciences, fostering specialized programs like Gulf Medical University's MSc in Neonatal Critical Care.
Check Al Ain higher ed jobs for pediatrics research opportunities.
Challenges and Implications for Policy and Families
While survival improves, morbidity burden strains resources—BPD prolongs stays, sepsis demands antibiotics. Families face counseling dilemmas at viability limits. Policymakers should prioritize multicenter registries, infection control, and long-term follow-up. UAE's Vision 2031 emphasizes maternal-child health investments.
Future Outlook: Balancing Survival and Quality of Life
Ongoing trials in surfactant therapy (e.g., prior Tawam Beractant vs. Poractant study) and AI predictive models promise gains. Multicenter UAE studies could benchmark nationally. Higher ed must expand neonatology fellowships amid rising preterms from ART.
Professionals seeking advancement: Visit higher ed career advice or rate my professor for UAEU insights.
Photo by Brett Jordan on Unsplash
Actionable Insights for Clinicians and Researchers
- Optimize antenatal steroids/MgSO4 in <32 weeks risks
- Enhance sepsis surveillance protocols
- Promote family-integrated care to mitigate BPD
- Collaborate via UAEU for prospective cohorts
- Explore research jobs in UAE neonatology
This Cureus publication positions UAE as a Middle East hub for preterm research, inviting global partnerships.
