The Novato Campus of the Buck Institute for Research on Aging serves as the primary and sole location for groundbreaking biomedical research dedicated exclusively to understanding the biology of aging and combating age-related diseases. As the world's first independent institute focused on geroscience, this state-of-the-art facility, designed by architect I.M. Pei, spans multiple interconnected buildings housing over 20 specialized laboratories. Researchers here investigate the malleable processes of biological aging to develop interventions that extend healthspan and improve quality of life.
- Neurodegeneration: Labs led by experts like Julie Andersen, Tara Tracy, and emeritus Dale Bredesen explore Alzheimer's, Parkinson's, axonal degeneration, cytoskeletal dynamics in neurons, and neuroprotective strategies including reversal of cognitive decline.
- Metabolism and Mitochondria: Pioneering work by Pankaj Kapahi, Gordon Lithgow, Simon Melov, and Nathan Price on nutrient sensing, mitochondrial dysfunction, bioenergetics, and energetic inefficiency in aging and diseases like diabetes.
- Immunology and Senescence: Research in the Campisi lab (Pierre-Yves Desprez) and others on senescent cells, chronic inflammation, immune dysregulation, and glia-neuron interactions in age-related pathologies.
- Cancer and Biomarkers: Chris Benz, Christina Yau, and Birgit Schilling focus on cancer biomarkers, protein-protein networks, pathway analysis, and senescent phenotypes in breast and other cancers.
- Systems and Phenomics: David Furman, Noa Rappaport (Center for Phenomic Health), and Lisa Ellerby employ multi-omics, clinical trials, and phenomic approaches to aging biomarkers and healthspan metrics.
- Stem Cells and Regenerative Medicine: Francesca Duncan and collaborations with UC campuses study ovarian aging, stem cell therapies, and regenerative potential in aging tissues.
- Infectious Diseases and Immunology: Adjuncts like Melanie Ott investigate HIV, SARS-CoV-2, and accelerated aging from viral infections, developing diagnostics and therapeutics.
The campus supports training for the next generation of aging scientists through immersive lab experiences, seminars, and interdisciplinary programs, emphasizing practical skills in cutting-edge geroscience techniques.
