Laboratory of Genetics and Genomics, National Institute on Aging Campuses

The Biomedical Research Center campus of the Laboratory of Genetics and Genomics at the National Institute on Aging specializes in understanding the genetic and genomic changes across the lifespan that influence aging traits. Located on the Johns Hopkins Bayview Campus, it houses cutting-edge research on the molecular mechanisms of aging, chronic age-related diseases, and potential interventions. Key principal investigators include Myriam Gorospe, Ph.D. (Chief), focusing on RNA-binding proteins and stress responses in aging; David Schlessinger, Ph.D., on genetics of human aging; Emmanouil Maragkakis, Ph.D., leading computational genomics; Weidong Wang, Ph.D., on gene expression regulation; and Yie Liu, Ph.D., on immune-related aging processes.

• Genetics and genomics of human aging and longevity
• Regulatory RNAs and post-transcriptional gene regulation in age-related decline
• Gene expression programs driving chronic pathologies like diabetes, neurodegeneration, and cancer
• Age-associated chromatin remodeling and epigenetics
• Single-cell gene expression analysis in aging tissues
• Cell senescence, inflammation, and development of senolytic compounds
• Computational genomics and bioinformatics for aging datasets
• Stress responses, muscle regeneration, and tissue repair mechanisms

Research at this campus integrates model organisms, human cohorts, and advanced omics technologies to translate findings into strategies combating age-related decline, without traditional teaching but offering training opportunities for postdocs and students in specialized research techniques.