Explore Exciting New Career Opportunities at Ragon Institute

The Ragon Institute Headquarters at 600 Main Street serves as the primary hub for groundbreaking research in human immunology and infectious diseases. This state-of-the-art LEED Gold-certified facility fosters collaboration among scientists, clinicians, and engineers from Mass General Brigham, MIT, and Harvard to accelerate the development of vaccines and therapeutics against HIV/AIDS, tuberculosis, and emerging pathogens like SARS-CoV-2. The campus emphasizes translational research, integrating basic science with clinical applications to harness the immune system's potential for global health impact.

• Immunology and Vaccinology: Advanced training in antibody discovery, T-cell engineering, and mucosal immunity.
• Infectious Disease Research: Studies on HIV pathogenesis, latency, and cure strategies; TB vaccine development.
• Biomedical Engineering: Humanized mouse models, microfluidics, and novel imaging technologies for immune monitoring.
• Computational Immunology: AI and machine learning for epitope prediction and immune repertoire analysis.
• Structural Biology: Cryo-EM and X-ray crystallography of immune receptors and viral antigens.
• Global Health and Clinical Trials: Programs on maternal-child transmission, broad-spectrum antivirals, and pandemic preparedness.

Core faculty lead specialized labs, providing hands-on graduate-level courses and workshops in these areas, training over 200 researchers annually in cutting-edge techniques.

The Technology Square facility at 400 Technology Square complements the headquarters by hosting specialized labs focused on computational modeling, virology, and early-stage discovery research. Located in the heart of Kendall Square, it supports interdisciplinary programs that bridge engineering and biology to innovate immune-based interventions. Key efforts include developing tools for single-cell analysis and predictive modeling of immune responses to pathogens.

• Computational and Systems Biology: Courses in bioinformatics, systems immunology, and data-driven vaccine design.
• Virology and Pathogenesis: Research training on viral evolution, host-virus interactions, and escape mutants.
• Protein Engineering: Techniques for designing therapeutic antibodies and bispecific molecules.
• High-Throughput Screening: Platforms for immune modulator discovery and functional genomics.
• Collaborative Immunology: Joint programs with MIT on synthetic biology and immune circuit engineering.
• Bioinformatics and AI: Workshops on machine learning applications in immunology datasets.

This campus houses select core faculty and provides essential infrastructure like BSL-3 labs, enabling focused graduate and postdoctoral training in quantitative immunology and technology development.