Antonino Zichichi - Graduated in 1953, a prominent physicist known for his contributions to particle physics and founder of the Ettore Majorana Foundation and Centre for Scientific Culture.
Giuseppe Fava - Graduated in Law, a notable journalist, playwright, and anti-Mafia activist, known for his work in exposing corruption.
Salvatore Quasimodo - Nobel Prize in Literature in 1959, although he did not graduate from Unime, he was closely associated with the University of Messina.
Francesco Renda - Historian and politician, known for his work on the history of Sicily and the Sicilian Mafia.