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Benjamin Segal, MD, serves as Chair and Professor in the Department of Neurology at The Ohio State University Wexner Medical Center, where he directs the Neuroscience Research Institute, co-directs the Neurological Institute, and holds the Stanley D. and Joan H. Ross Chair of Neuromodulation. Board-certified in neurology by the American Board of Psychiatry and Neurology, he earned his MD from the Warren Alpert Medical School at Brown University in 1988, completed an internal medicine internship at the University of Chicago Medical Center in 1989, neurology residency at NewYork-Presbyterian Hospital/Weill Cornell Medical Center in 1992, and postdoctoral training in neuroimmunology at the National Institutes of Health in 1993. Dr. Segal launched his academic career with MS research at the NIH, directed the multiple sclerosis division at the University of Rochester, and in 2007 joined the University of Michigan as Holtom-Garrett Family Professor of Neurology and director of the MS Center and Neuroimmunology Program, establishing it as a national referral center. Recruited to Ohio State in 2019, he oversees a laboratory with over $1.3 million in annual NIH funding.
The Segal Lab examines immune-central nervous system interactions underlying multiple sclerosis pathogenesis and repair, employing experimental autoimmune encephalomyelitis models alongside patient MRI and clinical data to study immune dysregulation, CNS infiltration, and neural interactions driving damage or remission. Research highlights include identification of novel myeloid cells fostering neuronal survival and axon regeneration post-trauma, informing biomarkers and therapies for MS, traumatic brain and spinal cord injury, and neuroinflammatory disorders. Author of more than 115 peer-reviewed publications in leading journals such as Nature Immunology, Annals of Neurology, The Journal of Clinical Investigation, Proceedings of the National Academy of Sciences, and Lancet Neurology, Dr. Segal has advanced precision medicine in neuroimmunology. Awards encompass annual recognition in Best Doctors in America and Castle Connolly Top Doctors since 2010, the National Multiple Sclerosis Society Harry Weaver Neuroscience Scholar Award, and Taubman Scholar status. He is President-elect of the Americas Committee for Treatment and Research in Multiple Sclerosis and a trustee of the National MS Society Ohio Buckeye Chapter.