Rate My Professor Chen Seng

Dr. Ng Chen Seng serves as a Lecturer, Principal Investigator, and Institutional Biosafety Committee Biosafety Officer in the Division of Medical Biosciences, School of Science at Monash University Malaysia. He earned a Bachelor of Science in Biotechnology from Universiti Malaysia Sabah in 2008, a Master of Science and Doctor of Philosophy in Life Sciences with a focus on Viral Immunology from Kyoto University, Japan, mentored by Professor Takashi Fujita. Additionally, he holds an Advanced Certification in Cell Biology from the Massachusetts Institute of Technology and a MicroBachelors in Neuroscience from Harvard University. Following his doctoral studies, Ng conducted postdoctoral research at the University of California, Los Angeles under Professor Alexander Hoffmann and at the University of British Columbia. He was appointed Senior Lecturer at Monash University Malaysia in 2022 and contributes to the Monash Neuroscience executive committee.

Ng's research specializes in innate immunity, virology, cell death, autophagy, signal transduction, and neuro-inflammation, addressing clinical challenges in autoimmune diseases, infections, inflammation, and amyotrophic lateral sclerosis. Notable discoveries include a STING-mediated Type II Interferon signature in SOD1-mutant ALS models, offering potential diagnostic and therapeutic targets, and explanations for species-specific differences in Type I and Type II interferon responses that accounted for failures in 1980s clinical trials. His key publications encompass 'Integrated transcriptomic profiling reveals a STING-mediated Type II Interferon signature in SOD1-mutant amyotrophic lateral sclerosis models' (Communications Biology, 2025), 'Linker Design for the Antibody Drug Conjugates: A Comprehensive Review' (ChemMedChem, 2025), 'Phytochemical-based nanosystems: recent advances and emerging application in antiviral photodynamic therapy' (Nanomedicine, 2025), 'Programmable self-replicating JEV nanotherapeutics redefine RNA delivery in ALS' (Communications Biology, 2025), and 'Shaping the future of antiviral Treatment: Spotlight on Nucleobase-Containing drugs and their revolutionary impact' (Bioorganic Chemistry, 2024). Ng has received the IBRO Rising Star Award from the International Brain Research Organization, Excellent Educator Awards for Semester 1 2023 and Semester 2 2024, the Heart Lung Innovation Research Institute Safety Award in 2020, and the Japanese Government Monbukagakusho MEXT Fellowship for Postgraduate Research in 2011. He accepts PhD students, leads projects such as the Neuro-innate immune hit perspective of neurotrophic viral infection, and has made 16 conference contributions including speaking at the La Jolla Immunology Conference and International Cytokine & Interferon Society Annual Meeting.