Rate My Professor James Amos-Landgraf

Amos-Landgraf's research employs genetically engineered mouse, rat, and pig models to investigate human colon cancer, focusing on molecular genetic and epigenetic mechanisms driving initiation and progression. His work examines sex disparities in disease susceptibility, revealing promotion by male hormones like testosterone rather than protection by female hormones, and explores the gut microbiota's role in linking host genetics, phenotype, epigenome, and cancer development. He pioneered longitudinal in vivo monitoring and forward genetics to identify susceptibility genes and potential chemotherapeutics, discovering a novel epigenetic pathway in early adenoma formation influenced by sex and microbiome. Key publications include 'Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones' (Proc Natl Acad Sci U S A, 2014), 'The utility of Apc-mutant rats in modeling human colon cancer' (Dis Model Mech, 2014), 'Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms' (Proc Natl Acad Sci U S A, 2012), and 'A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer' (Proc Natl Acad Sci U S A, 2007). His contributions enhance translatability of animal models, advancing diagnostics and prevention strategies in colon cancer research.