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Jeffrey N. Savas is an Associate Professor in the Departments of Neurology (Behavioral Neurology), Pharmacology, and Medicine (Nephrology and Hypertension) at Northwestern University Feinberg School of Medicine. He earned a Bachelor of Science in Biochemistry and Molecular Biology from the University of California, Santa Cruz, and a Ph.D. from New York University School of Medicine in 2009. He completed postdoctoral training as a fellow at the Scripps Research Institute, focusing on proteomics.
Dr. Savas leads the Savas Lab, which opened at Northwestern in 2015. His research specializes in dementia and aging, with expertise in proteomics and the study of protein turnover, proteostasis, and synaptic function. The lab investigates how impaired protein quality control contributes to neurodegeneration, Alzheimer’s disease pathogenesis, tau pathology, long-lived proteins in development and aging, and noise-induced hearing loss. Key projects examine synaptic vesicle machinery in Alzheimer’s models, tau phosphorylation dynamics, and strategies to enhance cochlear proteome fidelity. He is affiliated with the Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, Simpson Querrey Center for Neurogenetics, Simpson Querrey Institute for Epigenetics, Center for Autism and Neurodevelopment, and Denning Ataxia Center. Dr. Savas has contributed to studies on Alzheimer’s protein function and long-lived mitochondrial proteins, with work published in journals including Science and the Journal of Cell Biology. His lab employs mass spectrometry and stable-isotope labeling to map protein lifetimes and dysfunction across tissues.
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Explore the latest research from Northwestern University showing how cheap antiseizure drug levetiracetam could prevent Alzheimer's plaques via synaptic vesicles. Implications for US higher ed research.
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