Rate My Professor Joseph Goldstein

Joseph L. Goldstein, M.D., serves as Professor and Chair of the Department of Molecular Genetics at the University of Texas Southwestern Medical Center at Dallas. He also holds the Julie and Louis A. Beecherl, Jr. Distinguished Chair in Biomedical Research, the Paul J. Thomas Chair in Medicine, and the title of Regental Professor of the University of Texas. Goldstein earned a B.S. from Washington and Lee University in 1962 and an M.D. from UT Southwestern Medical Center in 1966. In collaboration with Michael S. Brown, he identified the low-density lipoprotein receptor and elucidated its role in cholesterol homeostasis, establishing the field of receptor-mediated endocytosis and contributing to the development of statin drugs. Their subsequent research identified the SREBP family of transcription factors and the mechanism of regulated intramembrane proteolysis that controls cholesterol and fatty acid synthesis.