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Jumpei Taguchi is Project Assistant Professor at the Core Laboratory for Developing Advanced Animal Models, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo. He earned a master's degree from the Graduate School of Chemical Sciences and Engineering at Hokkaido University in 2016 and a Ph.D. in engineering from Hokkaido University. His academic career includes prior affiliation with the Institute of Biomaterials and Bioengineering at Tokyo Medical and Dental University. Taguchi's research centers on genome editing technologies, with a focus on developing methods for full-length gene humanization in mice. In 2024 he received an Inamori Research Grant in biology and life sciences.
Taguchi co-led the development of the TECHNO method, a two-step CRISPR/Cas9-based genome editing strategy that enables efficient integration of large human genomic fragments into mouse embryonic stem cells. This approach was detailed in a 2026 publication in Nature Communications titled “A scalable two-step genome editing strategy for generating full-length gene-humanized mice at diverse genomic loci.” The technique has been applied to loci such as c-Kit, APOBEC3, and CYBB, producing models that exhibit human-like splicing, tissue-specific expression, and functional outcomes in hematopoiesis and spermatogenesis, as well as models incorporating disease-associated mutations. His work supports the creation of physiologically relevant humanized mouse models for studying gene function and disease mechanisms.
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University of Tokyo researchers unveil TECHNO, a two-step CRISPR method for creating advanced humanized mice that accurately reproduce intractable diseases like CGD, advancing Japan's biomedical frontier.
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