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Masaki Mandai is a Professor in the Department of Gynecology and Obstetrics at the Graduate School of Medicine, Kyoto University. He received his medical degree from the Kyoto University Faculty of Medicine in 1988 and his Ph.D. in Medicine from Kyoto University in 1997. Mandai has studied gynecologic cancer biology for more than twenty years. His research includes cancer immunology, which he began pursuing at the National Institutes of Health in 2000. He has led immunotherapy initiatives for gynecologic cancers and conducted the first clinical trial using an anti-PD-1 antibody for recurrent ovarian cancer. His work also covers molecular target therapy, precision medicine, comprehensive genome-wide analysis, and the use of artificial intelligence and machine learning to examine immunological profiles in gynecologic cancers.
In his role as Professor, Mandai oversees clinical and research activities across oncology, perinatology, reproductive medicine, and health care units within the department. These efforts include advancing minimally invasive surgical techniques such as laparoscopic and robotic procedures for gynecologic conditions and investigating tumor immunosuppressive mechanisms through omics analysis. Mandai teaches courses including Gynecology and Obstetrics and Women’s Oncology at the Faculty of Medicine. He has served on multiple university committees, including those related to international exchange and clinical anatomy. His research has resulted in numerous publications in obstetrics and gynecology, contributing to the understanding and treatment of gynecologic malignancies.
Kyoto University and Chordia Therapeutics unveil CTX-439, a CDK12 inhibitor enhancing PARP therapy in uterine serous carcinoma via HRD induction. Preclinical promise for Japan's rising endometrial cancer challenge.
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