Rate My Professor Sumeet Manandhar

Sumeet Manandhar completed his Doctor of Philosophy at the University of Otago's Department of Pathology and Biomedical Science in Christchurch, part of the Division of Health Sciences, in May 2024. His doctoral thesis, titled 'The Impact of Hydrogen Sulfide and Kupffer Cells on Endothelial Cell Adhesion Molecules Expression and Endothelial Dysfunction in Sepsis,' was supervised by Madhav Bhatia and Steve Chambers. Prior to this, he earned a Master's degree in Biomedical Science from Chosun University's Department of Biomedical Science and a Bachelor of Pharmacy from Purbanchal University's Little Buddha College of Health Science. As a PhD student, Manandhar was affiliated with the Inflammation Research Group and contributed to various studies on inflammatory mechanisms. Following graduation, he took up a position as a Postdoctoral Fellow in the Department of Dermatology at the University of Pittsburgh.

Manandhar's research focuses on the interplay of hydrogen sulfide (H2S) and other mediators like substance P in the pathophysiology of sepsis, emphasizing endothelial cell function, adhesion molecules, and Kupffer cell involvement. His investigations utilize polymicrobial sepsis models, such as cecal ligation and puncture, to explore how pharmacological inhibition or genetic deletion of key pathways affects multi-organ injury. Key publications from his work at Otago include 'Kupffer Cell Inactivation Alters Endothelial Cell Adhesion Molecules in Cecal Ligation and Puncture-Induced Sepsis' (Biomolecules, 2024, cited by 7), 'A Key Role of Adhesion Molecules on Endothelial Cells: Pharmacological Inhibition and Genetic Deletion Reveal Protection against Multi-Organ Injury in Sepsis' (International Journal of Molecular Sciences, 2023, cited by 8), 'Hydrogen Sulfide and Substance P Levels in Patients with Sepsis' (Life, 2022, cited by 7), and the book chapter 'Hydrogen Sulfide and its Interaction with Other Players in Inflammation' (2021, cited by 13). These contributions have advanced understanding of gasotransmitter roles in inflammation. Some research received support from the University of Otago Vice-Chancellor's Strategic Development Fund. His current interests extend to heparinoids and extracellular vesicles in dermatological contexts.