Rate My Professor Tamas Zakar

Conjoint Professor Tamas Zakar holds the position of Conjoint Professor in the School of Medicine and Public Health (Medical Biochemistry) at the University of Newcastle, Australia. A Doctor of Medicine with a PhD, he is affiliated with the Mothers and Babies Research Centre within the College of Health, Medicine and Wellbeing and maintains an office at the Hunter Medical Research Institute. His earlier career includes research roles at the University of Western Ontario and the Lawson Research Institute in London, Ontario, Canada, contributing to foundational studies on prostaglandin synthesis regulation in human amnion tissues during the 1990s.

Tamas Zakar's research centers on the biochemical and molecular regulation of human parturition and pregnancy maintenance. His investigations encompass prostaglandin synthesis and endoperoxide H synthase-2 expression in gestational tissues, epigenetic regulation of inflammatory genes in fetal membranes through histone modifications and DNA methylation during term and preterm labor, progesterone receptor isoform expression and withdrawal in myometrium, neuropeptide pathways influencing birth timing, regulation of 20α-hydroxysteroid dehydrogenase in myometrium related to fetal sex and maternal body mass index, inflammatory networks in preterm labor with and without chorioamnionitis, bromodomain and extra-terminal proteins in decidual cell inflammatory gene control, and the renin-angiotensin system in intrauterine tissues. He has secured National Health and Medical Research Council (NHMRC) project grants, including for epigenetic regulation of inflammatory genes in fetal membranes relevant to term and preterm birth. Key publications include "20α-Hydroxysteroid Dehydrogenase Expression in the Human Myometrium at Term and Preterm Birth: Relationships to Fetal Sex and Maternal Body Mass Index" (Reproductive Sciences, 2023), "Regulation of inflammatory genes in decidual cells: Involvement of the bromodomain and extra-terminal family proteins" (Frontiers in Immunology, 2023), "Preterm labor with and without chorioamnionitis is associated with activation of myometrial inflammatory networks: A comprehensive transcriptomic analysis" (American Journal of Obstetrics & Gynecology, 2022), "Histone Deacetylase Inhibitors: Providing New Insights and Therapeutic Avenues for Unlocking Human Birth" (Frontiers in Physiology, 2021), "Preterm Labor is a Distinct Process from Term Labor following Computational Analysis of Human Myometrium" (American Journal of Obstetrics & Gynecology, 2021), "How does progesterone relax the uterus in pregnancy?" (New England Journal of Medicine, 2011), and "Prostaglandin Synthesis Regulation in Human Amnion Tissue" (Biology of Reproduction, 1992). His publications have accumulated over 3,500 citations.