4D printed Biomaterials in cancer therapeutics
About the Project
According to WHO, cancer is the second leading cause of death worldwide, with nearly 1 in 6 deaths been due to cancer. The principal modes of cancer management are surgery, radiotherapy, chemotherapy and pharmaceutical agents. However, there are many side effects from extant treatments e.g., invasiveness of surgery, and with other treatments being systemic in nature; therefore, only a small fraction of the drugs reaches the tumour site. Due to the short period of actions, repeated doses are often required, which can lead to exacerbation of side effects and inconvenience. Due to these obstacles, targeted or localized release technology coupled with long-acting treatment functionality is a key research theme to replace systemic administration therapies and show potential for advancing cancer treatment including capability of personalizing the treatment. One especially promising therapeutic option gaining prominence is the use of multifunctional implants combining tumour-killing ability while promoting bone resorption/growth. Therefore, the main goal of this project is to investigate new approaches for targeted long-acting drug release for effective cancer therapies based on 3D & 4D printed / bioprinted drug-loaded implants.
Subject area
Cancer management, Bioprinting, Biomaterials, drug delivery
Candidate requirements / Key skills required for the post
Applicants should have a 1st or 2.1 honours degree (or equivalent) in a relevant subject. Relevant subjects include Pharmacy, Pharmaceutical Sciences, Biochemistry, Biological/Biomedical Sciences, Chemistry, Engineering, or a closely related discipline. Students who have a 2.2 honours degree and a Master’s degree may also be considered, but the School reserves the right to shortlist for interview only those applicants who have demonstrated high academic attainment to date.
Relevant links / more information
http://www.qub.ac.uk/schools/SchoolofPharmacy/Research/PostgraduatePositions/
http://www.qub.ac.uk/schools/SchoolofPharmacy/Research/
Keywords for search filters
3D Printing, 4D printing, Bioprinting, Drug Delivery, Cancer treatment, Implants
Training provided through the research project
The successful applicant will be integrated into QUB research groups of experienced researchers with access to world-leading facilities. The techniques that will be used during the project cover a wide-range and include: Atomic Force Microscope (AFM), Computed Tomography (CT), Contact Angle Goniometry (CAG), Differential Scanning Calorimetry (DSC), Fourier-Transform Infrared (FTIR) Spectroscopy, Rheology, Scanning Electron Microscopy (SEM), Bioprinted equipment and software, In Vitro Release Studies, and modelling.
Expected impact activities
The PhD student would be encouraged to engage in a variety of impact activities, disseminate the research project findings through public talks, and participate in QUB showcase events. Examples of impact activities includes: Blogs or web articles, Magazine articles, Public lectures, School visits, oral & poster Presentations (at local, national and international conferences), and Publication of scientific papers in peer reviewed journals.
Funding Notes
This project is not funded; applications are welcome from self-funding candidates.
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