Closing the loops: Unleashing the poteintial mTORC2.
Medical Research Council (Cambridge) — Laboratory of Molecular Biology
Dr R Williams
Tuesday, December 08, 2026
Competition Funded PhD Project (Students Worldwide)
Cambridge, United Kingdom
Biochemistry, Cancer Biology, Molecular Biology
About the Project
mTORC2 can integrate multiple activating influences to positively influence anabolism, survival and cytoskeletal remodelling. We have characterised a positive feedback loop between mTORC2 and AKT and have shown that mTORC2 has a great potential for activation that has been overlooked in previous work. We have structurally characterized the mechanism for the mTORC2 activation, and we are elucidating the roles of positive feedback loops involving other AGC kinases. These mechanisms are central to…
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