"Core Facility Manager (Transgenic & Gene Targeting)"

Posting Start Date: 20/02/2026

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Job Description

The Head of the Transgenic Mouse Facility provides scientific, operational, and strategic leadership for an institutional core facility supporting the generation, breeding, and management of genetically engineered mouse models. This role oversees facility operations, staff, technology platforms, and compliance, while partnering closely with investigators to enable high-quality, reproducible research.

This position operates in a laboratory and animal facility setting and requires adherence to institutional safety and animal care policies.

Duties And Responsibilities

Scientific & Technical Leadership

• Lead the design, implementation, and optimization of transgenic and genome-editing technologies (e.g., CRISPR/Cas9, ES cell targeting, conditional alleles).
• Direct rederivation services (e.g., embryo transfer, IVF-based rederivation) to ensure colony health and biosecurity.
• Oversee sperm and embryo cryopreservation services, including experimental design, execution, quality control, and recovery validation.
• Provide expert consultation to investigators on experimental design, feasibility, timelines, and model selection.
• Stay current with emerging technologies and drive continuous improvement of facility capabilities.

Facility & Operations Management

• Direct day-to-day operations of the transgenic mouse facility, including scheduling, workflow optimization, and resource allocation.
• Oversee colony management strategies in coordination with animal care and veterinary teams at CM.
• Oversee a centralized cryobank, including inventory control, database management, labelling, storage integrity, and disaster recovery planning.
• Develop and enforce SOPs for cryopreservation, thawing, reanimation, and long-term storage.
• Develop and manage facility budgets, pricing, and capital equipment planning.
• Establish and maintain SOPs to ensure efficiency, quality, and reproducibility.

Financial Management & Cost Recovery

• Develop and manage facility budgets, recharge rates, and service pricing.
• Oversee the collection of annual cryostorage fees for sperm and embryo samples and ensure transparent communication of costs and policies to investigators.
• Monitor cost recovery, utilization metrics, and long-term financial sustainability of the facility and cryobank operations.
• Participate in capital planning for specialized equipment and infrastructure.

Personnel Management

• Recruit, train, supervise, and mentor facility staff, promoting technical excellence and a collaborative culture.
• Ensure staff proficiency in advanced reproductive technologies, cryopreservation methods, and regulatory compliance.
• Conduct performance evaluations and support professional development.

Compliance & Quality Assurance

• Ensure full compliance with institutional, local, and federal regulations (IACUC, AAALAC, animal welfare standards).
• Maintain accurate records for transgenic production, rederivation, cryopreservation, and storage activities.
• Collaborate with veterinary, compliance, and biosafety teams to maintain high standards of animal health and data integrity.

Collaboration & Institutional Engagement

• Serve as a key liaison between the facility and the research community.
• Contribute to grant applications, publications, and institutional initiatives involving mouse model development.
• Participate in strategic planning for core facilities and research infrastructure.

Any Other Duties:

• Perform other job-related duties as assigned

Qualifications

Required Qualifications

• PhD, DVM, or equivalent advanced degree in genetics, molecular biol