Developing Next‑Generation Boron Compounds for BNCT Cancer Therapy
About the Project
We invite applications for a PhD project focused on the design, synthesis and evaluation of novel boron-rich small molecules for Boron Neutron Capture Therapy (BNCT). BNCT is a targeted radiotherapeutic strategy with growing clinical momentum but a critical unmet need for improved boron delivery agents. Critically, at the University of Birmingham we have the only neutron source in the UK for BNCT research.
The successful candidate will work at the interface of synthetic medicinal chemistry, analytical chemistry, and translational radiotherapy, developing new boron chemotypes with enhanced tumour uptake, retention and selectivity. The project will involve iterative molecule design, synthesis, and physicochemical/biological characterisation, with opportunities to collaborate with experts in cancer biology, imaging and BNCT-relevant assay development.
Research aims
The final scope will be tailored to the successful applicant and may include:
- Boron cluster and boron-rich scaffold design (e.g., carboranes/boron cages and alternatives)
- Prodrug, targeting-ligand, or transporter‑engaging strategies to improve tumour delivery
- Structure–property relationships to optimise solubility, stability and cellular accumulation
- In vitro testing and mechanistic studies; potential progression toward in vivo evaluation via collaborators
Candidate profile
A strong undergraduate or Master’s degree (or equivalent) in Chemistry or a related discipline. Ability to work independently, manage lab work safely, and communicate results clearly in different formats. English language proficiency meeting institutional requirements.
Desirable
Demonstrable interest in experimental lab-based research (synthetic chemistry).
Training and environment
You will join a supportive, collaborative research environment with access to modern synthetic and analytical facilities and a network of translational partners. The project offers excellent preparation for careers in medicinal chemistry, radiopharmaceutical/therapeutics R&D, or academic research.
How to apply
Informal enquiries to a.m.jones.2@bham.ac.uk; j.p.coverdale@bham.ac.uk; j.parsons.3@bham.ac.uk. Please enclose a CV (including research experience and any publications) and cover letter (1–2 pages) describing your interest in this research project, how it aligns to your previous experience, and what you would like to gain from studying for a PhD.
Deadline: Open until filled (early enquiries encouraged)
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