Developing redox-sensitive molecular binders of proteins for biotechnology and biomaterial applications

About the Project

Project Summary

This fully funded 3.5-year PhD position aims to create new molecular tools that establish redox-sensitive binding interactions between small molecules and proteins for applications in biotechnology and programmable biomaterial synthesis.

The ability to program the behaviour of biomolecular chemistry is foundational for developing new biotechnology applications. Redox-sensitive molecules are a handle to control biomolecular chemistry as their behaviour (e.g. binding interactions) can be programmed with electrochemical signals. Establishing electrochemical control over the interactions between small-molecules and proteins will unlock a range of new programmable biotechnologies.

In this PhD, you will prepare novel redox-sensitive small molecules by organic synthesis, quantify their binding interactions with proteins and establish electrochemical control of their binding to proteins. You will apply these novel tools to the development of biotechnology applications such as the assembly of bio-based patterned hydrogels and the isolation and purification of proteins (akin to pull down assays).

This project is supported by the University of Birmingham and linked to a European Research Council Starting Grant awarded to Dr. Oliver Maguire. For more information, see: https://www.maguire-research-group.com/

Training and Mentoring

You will learn a multidisciplinary set of practical skills including organic synthesis, analytical techniques (e.g. NMR / fluorescence / UV-Vis spectroscopy, mass spectrometry and HPLC), electrochemistry, isothermal titration calorimetry and fabrication of hydrogel soft matter. You will be mentored by Dr. Maguire and will learn how to design and manage projects, how to conduct research, how to give impactful presentations, how to write scientific papers and how to effectively collaborate with others to deliver ambitious goals. The generous support of the European Research Council you will attend international and national conferences to present your work and network with other scientists from across the globe. At the end of your PhD, you will be an accomplished and highly-capable scientist and ready to confidently take the next step forward in your career, be that in academia, industry or the public sector.

Who we are looking for

We are looking for candidates who are passionate about chemistry and their personal development. Candidates should have or expect to receive a first or upper second (2.1) Master's degree (or equivalent) in chemistry or a related discipline. A successful applicant will have an independent and diligent work ethic with a keen interest in the project. Familiarity with organic synthesis, chemical biology and hydrogels is advantageous.

The Maguire Research Group (Maguire-Research-Group.com)

We work in the field of Systems Chemistry and we construct life-like systems from the bottom-up. We aim to enrich artificial materials with new life-like behaviour. We are based in the School of Chemistry’s new Molecular Sciences Building at the University of Birmingham. The School is a vibrant community of researchers whose interests span a range of chemical disciplines.

Application process

Interested candidates should first contact Dr. Maguire for informal enquires at o.r.maguire@bham.ac.uk; please include a CV and a Cover letter outlining your research interests and why you are interested in the role. There is no closing date but please apply ASAP as the position will be filled when the right candidate is found. The School of Chemistry is keen to achieve a gender and diversity balance across the School and welcome applicants from all backgrounds. The School holds an Athena SWAN Bronze Award, which recognises its work in promoting women’s careers in science, technology, engineering, mathematics and medicine in higher ed..

Funding Notes

This studentship is fully funded for 3.5-years and includes a tax-free annual stipend at the UKRI level. Due to funding restrictions, only those with UK home status may apply.

References

[1] J.Li; W.E.Bentley; G.F.Payne et al. Biofabrication 2019, 11, 032002.
[2] E.R. Cross, SN Appl Sci 2020, 2, 1.
[3] O.R.Maguire; A.C.O’Donoghue et al. Chem. Commun. 2020, 56, 6114.