Targeted protein degraders, including PROTACs, are an exciting new class of therapeutic molecules that induce the destruction of disease-relevant proteins. However, there remains a major need for analytical tools that can rapidly and directly measure how these molecules function. These studentships will develop next-generation mass spectrometry methods to characterise degrader-induced protein complexes and ubiquitination processes, with applications in both academia and the pharmaceutical industry.
The projects will involve:
- Development of native mass spectrometry methods for analysing PROTAC complexes and ubiquitination.
- Investigation of ternary complex formation and functional degradation outcomes.
- Development of in vitro and cellular ubiquitination assays.
- Automated sample delivery and high-throughput analytical workflows.
- Analysis of complex biological samples using state-of-the-art instrumentation.
The students will receive extensive training in:
- Native protein mass spectrometry and ion mobility
- Protein biophysics and structural biology
- Quantitative analysis of protein complexes
- Method development and analytical instrumentation
- Scientific communication and presentation skills
The two studentships are closely aligned scientifically and will contribute to a shared overarching goal, providing a highly collaborative and supportive research environment.
If you wish to discuss any of the details informally, please contact Dr Rebecca Beveridge (rebecca.beveridge@strath.ac.uk).
Entry Requirements:
A very good undergraduate degree (at least a UK 2:1 honours degree, or its international equivalent).
How to apply:
Please send your C.V., a cover letter and details of two referees to Dr Beveridge (rebecca.beveridge@strath.ac.uk). The cover letter should outline why you’re interested in this project and describe your relevant experience.
