The project will use a combination of bioinformatics and statistical tools with molecular biology techniques to investigate how sequence variants, epitranscriptomic processes and RNA modification profiles differ between populations of healthy and non-healthy individuals. We will perform functional studies in mutated neuronal cells and assess human brain tissue to understand changes at the synapse and other important cell subcompartments. The findings of such studies should improve our understanding of how genetic architecture relates to biological and pathophysiological processes which contribute to the expression of brain disease.

The project will last 3 or 4 years and will be available full-time. Both Home and International students are welcome to apply.

The project will use a combination of bioinformatics and statistical tools with molecular biology techniques to investigate how sequence variants, epitranscriptomic processes and RNA modification profiles differ between populations of healthy and non-healthy individuals. We will perform functional studies in mutated neuronal cells and assess human brain tissue to understand changes at the synapse and other important cell subcompartments. The findings of such studies should improve our understanding of how genetic architecture relates to biological and pathophysiological processes which contribute to the expression of brain disease.

The project will last 3 or 4 years and will be available full-time. Both Home and International students are welcome to apply.