About the Project
R-loops are non-canonical RNA/DNA structures, formed in all living organisms where they play crucial roles in regulating gene expression, DNA and histone modifications, generation of antibody diversity, DNA replication and genome stability. The work from the lab have demonstrated that R-loops are also implicated in human diseases, including neurodegeneration and cancer. However, the molecular mechanisms associated with R-loop functions in health and disease are not fully understood.
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