G protein coupled receptors (GPCRs) remain one of the key therapeutic targets for the treatment of disease, and while much is known about their pharmacology, it is increasingly clear that the signaling mechanisms used by a specific receptor to modulate cell functions is context specific. Adrenal chromaffin cells have a vital role in the body's response to stress; through the secretion of catecholamines they mediate the 'fight-or-flight' response resulting in increased heart rate, blood pressure…

G protein coupled receptors (GPCRs) remain one of the key therapeutic targets for the treatment of disease, and while much is known about their pharmacology, it is increasingly clear that the signaling mechanisms used by a specific receptor to modulate cell functions is context specific. Adrenal chromaffin cells have a vital role in the body's response to stress; through the secretion of catecholamines they mediate the 'fight-or-flight' response resulting in increased heart rate, blood pressure…