Harnessing Engineering Biology Approaches to Remove Antimicrobial Contamination from Water
About the Project
This project is being advertised as part of the Engineering Biology for Environmental Applications Doctoral Focal Award, led by Cranfield University. The project carries a UKRI TechExpert enhanced annual stipend of £31,805 available to students with Home fee status.
A key driver of the current antimicrobial resistance crisis is the high levels of antibiotics contaminating our water. In this project we aim to harness enzyme-based solutions in combination with engineered living materials (ELMs) to remove antimicrobial contamination from wastewater systems both locally and at the plant scale.
Objective 1: Enzyme Engineering: We will modify a range of different antimicrobial degrading enzymes to enhance their efficacy, solubility, thermotolerance and stability with support from AI company Kuano.
Objective 2: Immobilizing antimicrobial degrading enzymes on ELMs: We will utilize covalent bonding approaches to fuse engineered enzymes of interest with biotic materials in collaboration with CarbonCell.
Objective 3: Integrating engineering systems into model waste management systems: Here we will explore a range of different approaches to integrate our ELM into hospital waste management systems.
Lead supervisor: Prof. Ronan McCarthy, Professor of Microbial Biofilms, University of Southampton.
This project is offered by University of Southampton. Due to funding restrictions, this project is only open to students eligible for Home rate fees.
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