About the Project
De novo protein folding is the fundamental process by which a polypeptide chain acquires its native conformation for the first time. All proteins are synthesised by the ribosome and can begin to fold co-translationally as the nascent chain emerges vectorially from the ribosome exit tunnel, exploring an evolving energy landscape shaped by translation kinetics, the ribosome, and molecular chaperones. Understanding how a protein reaches its native state therefore requires resolving folding both…
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