About the Project
Mycobacterium tuberculosis infects macrophages and can commandeer their machinery to survive intracellularly. Infected macrophages aggregate into granulomas, hallmark immunopathological structures of TB. Often, granuloma macrophages clear infection; however, mycobacteria can exploit granulomas for disease progression. In particular the bacteria can cause apoptosis (programmed cell death) of infected macrophages after which uninfected macrophages are recruited to engulf the dying cells and their…
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