Inflammatory bowel disease is an umbrella term for a group of debilitating, chronic, and difficult to treat diseases that affect millions worldwide. In these diseases, intestinal fibroblasts acquire immunoregulatory roles and establish detrimental interactions with immune cells that contribute to therapy resistance. However, the mechanisms governing this remain poorly understood. My lab identified an epigenetically-coded memory program in fibroblasts from resections of therapy-resistant IBD…
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