About the Project
A fully funded PhD studentship is available in the research group of Dr Maya Al-Sid-Cheikh (School of Chemistry, University of Edinburgh), who will act as the Main/Principal Supervisor and will lead the project. The student will also benefit from specialist input through co-supervision with Dr Marc-Andre Cormier (School of Geographical & Earth Sciences, University of Glasgow) and Prof Mark Miller (Institute of Neuroscience and Cardiovascular Research, CMVM, University of Edinburgh).
Project Summary
This project examines the environmental and health impacts of titanium dioxide (TiO₂) and toxic metal exposures in a Canadian town near a titanium mining site. Strong winds disperse TiO₂ ore and metallic particulates from an unprotected deposit, affecting the community and marine environment. The long-term health effects of TiO₂ exposure, particularly through inhalation, remain debated. The International Agency for Research on Cancer classified TiO₂ as “possibly” carcinogenic to humans, citing insufficient evidence due to limited human data, especially regarding the influence of particle size.
This study aims to address key knowledge gaps by: i) identifying health impacts in the affected population, ii) establishing links between TiO₂ (and other metals) and health outcomes, and iii) determining whether particle size or other properties drive these associations. Findings will inform occupational exposure discussions, given the global manufacture and handling of TiO₂ nanoparticles.
This project will quantify and characterise particulate pollution from titanium ore, assess its toxicological risks, and explore associations with cancer incidence, to support targeted public health interventions for communities near mining operations.
Research objectives (Core and conditional components)
The project has three linked work packages:
- Exposure characterisation (CORE): Collect and characterise TiO₂‑bearing and metal particulates in air; establish an isotopic fingerprint of Ti using multi‑collector ICP‑MS/ICP-QQQ-MS/SP-ICPMS; and map dispersion using an isoscape/ISOSCAPE‑style framework.
- Mechanistic toxicology (CONDITIONAL): Evaluate oxidative stress/inflammation pathways and dose–response relationships using appropriate model systems, including in vitro, ex vivo, and zebrafish models where justified. Progression to more complex in vivo mammalian work is contingent on (i) robust exposure data, and (ii) all relevant ethics/Home Office approvals.
- Epidemiology/public health (CONDITIONAL): In collaboration with clinical/public‑health partners, explore associations between exposure indicators and relevant health outcomes using suitable, ethically approved datasets.
Important: The priority is to deliver Work Package 1 to ensure the project is scientifically sound and deliverable within the PhD timeframe. Work Packages 2–3 are dependent on satisfactory progress and the required regulatory approvals.
Training and What You Will Do
You will receive training and close support to develop skills in:
- Analytical method development for particle/dust characterisation (e.g., ICP‑MS platforms, sample preparation, QA/QC).
- Isotope ratio measurements and interpretation (including multi‑collector ICP‑MS).
- Air sampling concepts and evaluation of existing sampler designs (literature‑led appraisal, prototyping where appropriate).
- Spatial data handling and dispersion/isoscape modelling (with training in relevant tools).
- Research integrity, ethics, data management, and interdisciplinary communication.
Applicant Profile
Essential:
- A strong MSc degree (or undergraduate; minimum 2:1 grade) in analytical sciences (analytical chemistry, geochemistry, environmental chemistry) with interests in ecotoxicology, and public health.
- Demonstrable laboratory experience and good practice (e.g., analytical chemistry, trace metal analysis, mass spectrometry, sample preparation, QA/QC).
- Evidence of strong organisation, independence, and the ability to deliver agreed tasks to deadlines.
- Excellent written and verbal communication skills and willingness to work collaboratively in an interdisciplinary team.
Desirable:
- Experience with ICP‑MS/MC‑ICP‑MS/AAS, particle analysis, or isotope geochemistry (e.g. TI-MS, nanoSIMS).
- Experience with environmental sampling, aerosols/dust, or fieldwork planning.
- Familiarity with spatial/GIS tools (e.g. ArcGIS, QGIS), modelling, or programming for data analysis (e.g., R/Python).
- Interest or experience in toxicology, epidemiology, or risk assessment (training will be provided).
How to Apply
Applications should be submitted by email to Dr Maya Al-Sid-Cheikh (malsid@ed.ac.uk) with the subject line “PhD TiO₂ Mining Exposure – Application 2027”
Please include all of the following documents. Incomplete applications will not be considered.
- Cover letter (required, max 2 pages) addressing:
- Your motivation for this project;
- Relevant technical experience; and
- How you work productively with supervision, including planning, written updates, communication.
- Curriculum Vitae (required, max 3 pages) including:
- Technical Skills section covering sample preparation (e.g., digestion/clean handling where relevant), analytical methods/instruments, and laboratory practices (e.g., QA/QC).
- Technical Skills Snapshot (½–1 page, required): bullet list of methods/instruments plus responsibility level (trained / assisted / independent), and (where applicable) the type and number of samples/matrices you worked with.
- A summary of research projects and your contribution, and
- Any research outputs (publications, posters, talks — if applicable).
- Academic transcripts (required, unofficial acceptable at first stage).
- Referees (required): Provide the names and contact details of three referees. For each referee, include:
- Their role/position,
- How long they have known you,
- In what capacity (e.g., supervisor, course organiser, line manager), and
- What aspects of your work they can comment on.
References may be requested at shortlist stage.
- School of Chemistry EDI Form receipt number (required): School of Chemistry Equality, Diversity and Inclusion Form (see below)
TIMELINE
Recruitment is on a rolling basis, and the position will remain open until filled. Applications will be reviewed as they are received; early application is encouraged. Start expected in October 2027.
IMPORTANT
Before Submitting your cover letter and CV, please complete the online School of Chemistry Equality, Diversity & Inclusion Form for 27/28 Entry.
The form will automatically generate a unique ‘Receipt Number’ that you must include in your cover letter.
Equality and Diversity
The School of Chemistry holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. The University is a member of the Race Equality Charter and is a Stonewall Scotland Diversity Champion, actively promoting LGBT equality. The University has a range of initiatives to support a family friendly working environment. See our University Initiatives website for further information. University Initiatives website: https://www.ed.ac.uk/equality-diversity/help-advice/family-friendly
Funding Notes
The studentship is fully funded for 42 months by the University of Edinburgh and covers tuition fees and an annual stipend at the UKRI rate (£21,805 for 2026-27; per annum), for a candidate satisfying EPSRC residency criteria. View Website
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