About the Project
Our group studies mechanisms of brain health, ageing and disease focusing on the lysosomal protein transmembrane protein 106B (TMEM106B) which forms amyloids in the brain in an age-dependent manner. TMEM106B genetic variants have also been found to modulate healthy ageing and disease risk in frontotemporal lobal degeneration and Alzheimer's disease. However, the underlying mechanisms behind TMEM106B and its implications for ageing and neurodegenerative disease are as yet, unknown.
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