Molecular Mechanisms of Insect Olfaction Toward Sesquiterpenoid Stereoisomers

About the Project

How do insects distinguish between mirror-image molecules, and why can a subtle change in stereochemistry transform a strong attractant into a compound that elicits no response? This PhD project explores the molecular mechanisms that drive insect recognition of sesquiterpenoid stereoisomers, a class of compounds commonly involved in true bug pheromone communication. By uncovering how insects detect and discriminate between these stereoisomers, the project will generate fundamental insights into insect olfaction while informing the design of cost-effective, stereochemically optimised lures for horticultural pest monitoring. The student will apply an interdisciplinary toolkit—spanning synthetic chemistry, electrophysiology, molecular biology, protein–ligand biochemistry, and behavioural ecology—to determine how odorant receptors (ORs), odorant-binding proteins (OBPs), and olfactory neurons respond to purified nerolidol enantiomers and geometric isomers. This will include synthesising key sesquiterpenoids; recording antennal and neuronal responses using GC–EAD, EAG, and single sensillum recordings; identifying and expressing candidate OBPs and ORs; conducting ligand-binding assays and computational modelling; analysing structure–function relationships across stereoisomers; and performing behavioural assays such as Y-tube olfactometry. The project offers the opportunity to publish high-impact findings across chemical ecology, molecular biology, and sensory neuroscience.

Candidate Requirements

We welcome motivated applicants with backgrounds in chemistry, biochemistry, molecular biology, or related fields.

• To be competitive in the scholarship ranking process, a GPA above 3.9/4.0 is essential.
• Experience in synthesis, analytical instrumentation, or materials science.
• Applicants should demonstrate strong problem-solving ability and a clear interest in interdisciplinary research.

Please email your CV and academic transcripts from both your Bachelor’s and Master’s degrees to Dr Soo-Jean Park at soojean.park@mq.edu.au.

Inquiries submitted without academic transcripts will not be answered.