patch clamp electrophysiology, we recently discovered that activation of GLP-1Rs promotes the formation of stable fusion pores in adrenal chromaffin cells to facilitate peptide secretion. The aim of this project is to identify the signaling events and molecules controlling exocytosis which are regulated by GLP-1 receptors in neuro-endocrine cells. Investigations into ligand and location bias within this context could aid the development of the next generation of GLP-1 agonists for the treatment of diverse neurological and cardiovascular disorders.

patch clamp electrophysiology, we recently discovered that activation of GLP-1Rs promotes the formation of stable fusion pores in adrenal chromaffin cells to facilitate peptide secretion. The aim of this project is to identify the signaling events and molecules controlling exocytosis which are regulated by GLP-1 receptors in neuro-endocrine cells. Investigations into ligand and location bias within this context could aid the development of the next generation of GLP-1 agonists for the treatment of diverse neurological and cardiovascular disorders.