MSc by Research: Understanding the functions of ERphagy via its targeted cargos

About the Project

The selective degradation of the endoplasmic reticulum via autophagy, also known as ERphagy, is a fundamental cellular process that has been observed under different stresses and stimuli. However, the exact rationale and contribution of ERphagy towards cellular homeostasis remains unclear, let alone its clinical implications. Recent emerging data suggest that dysregulation of ERphagy might contribute to neurodevelopmental defects, pancreatic stress, and cancer progression, albeit with unclear mechanisms. This project will aim to compare the autophagy cargo content during different stress induced ERphagy by mass spectrometry. We will then employ CRISPR-based interference and activation approaches (CRISPRi and CRISPRa) to understand the rationale for removing these cargos, and the impact of their failed removal on ER and overall cellular homeostasis.

Our research community thrives on the diversity of students and staff which helps to make the University of Dundee a UK university of choice for postgraduate research. We welcome applications from all talented individuals and are committed to widening access to those who have the ability and potential to benefit from higher education.

Please see our website for further details on the programme and how to apply:

Life Sciences MSc by Research MSc by Research (Postgraduate) : Study : University of Dundee

Please note before submitting your application that you must list your top three project choices in the Research Proposal section of the application form.

When you complete your application form, you should include your top 3 project choices, 2 letters of reference, uploaded under "Other Information" > "Supporting documents" and a personal statement. Failure to do so will delay your application.

Please note when submitting an application, please note our intake deadlines on the ‘how to apply’ section of our website.