Novel multifunctional hydrogel wound dressings for diabetic foot ulcer healing

About the Project

Diabetic foot ulcers (DFU) present a significant clinical challenge, affecting millions worldwide and often leading to severe complications, including infection and amputation. Standard treatments frequently fall short due to issues such as slow wound healing, susceptibility to bacterial infection, and inadequate moisture control. Hydrogels offer a promising approach due to their inherent ability to maintain a moist environment and deliver therapeutic agents; however, conventional hydrogels lack the multifunctionality required to address the complex needs of DFU healing.

This project aims to design and evaluate a novel multifunctional hydrogel dressing specifically for DFU treatment, focusing on accelerated wound healing and infection prevention. The hydrogel will be engineered to provide an optimal moist environment, support tissue regeneration, and possess inherent antibacterial properties to reduce infection risk. The primary objectives include assessing the hydrogel’s efficacy in promoting cellular growth, analyzing its ability to prevent biofilm formation, and ensuring biocompatibility with diabetic wound tissue.

The research will focus on synthesizing hydrogels incorporating bioactive agents with anti-inflammatory, antimicrobial, and tissue-regenerative properties. These agents will be embedded within the hydrogel matrix for sustained release, addressing the dual need for infection control and tissue healing. Laboratory testing will include in vitro studies to assess mechanical durability, moisture retention, and cellular response, followed by in vivo testing in diabetic wound models to confirm effectiveness. This comprehensive approach aims to establish a new standard in DFU care by combining multifunctionality and targeted healing support.

This project will provide experience in materials science, microbiology, immunology, and mathematical modelling. The candidate will benefit from broad training in materials science, organic chemistry, microbiology, inflammatory science, characterization techniques, and surface fouling assay techniques. Presentation, writing and interpersonal skills will be developed. The student will also have access to a wide range of training opportunities provided by the university's graduate school programme.

Relevant links / more information

http://www.qub.ac.uk/schools/SchoolofPharmacy/Research/

Keywords for search filters

infection; surface; coating; biofilm; polymer; hydrogel

Funding Notes

This project is not funded; applications are welcome from self-funding candidates.