Offer Description
Job description
The tumor microenvironment (TME) plays an important role in determining how tumors respond to radiotherapy. Features such as stromal composition, hypoxia, and cellular senescence can contribute to radioresistance and may therefore represent potential therapeutic targets.
In this PhD project, you will investigate how modulation of the TME can enhance the response to radiotherapy. The project will combine patient-derived models and in vivo tumor models to study how different TME characteristics contribute to treatment response and to explore potential strategies to target these mechanisms. A range of complementary preclinical approaches is used, including hypoxia modulation, targeting of senescent cells or cancer associated fibroblasts (CAFs), (image-guided) radiotherapy and immune checkpoint inhibition. Treatment response and underlying mechanisms will be assessed through readouts such as DNA damage and repair, tumor growth and characterization of the TME. The precise experimental approaches will be guided by the scientific findings and direction of the project.
Requirements
Profile
Requirements
- An MSc degree in Biomedical Sciences, Biology, Cancer Biology, or a related field, or an equivalent degree,
- A strong interest in preclinical cancer research,
- Motivated to investigate biological mechanisms underlying treatment response,
- Curious, enthusiastic about experimental science, and enjoy working in an interdisciplinary research environment.
Experience with molecular and cellular biology, tumor biology, radiobiology or immunology is an advantage. Experience with preclinical animal models is welcome, and candidates holding an Article 9 certificate for working with experimental animals are especially encouraged to apply.
Additional Information
Benefits
- With us, you receive 8% holiday allowance, an 8.3% end-of-year bonus, and – depending on your role – an irregular hours allowance ranging from 47% to 72%. In addition, you are entitled to 176 vacation hours per year (based on a 36-hour work week).
- Compensation: You will receive a €0.18 per kilometer travel allowance. Public transport costs (2nd class) are fully reimbursed. If you work partly or entirely from home, you will receive €2.40 per home-working day. This way, everything is well arranged—wherever you work.
- Flexible benefits scheme: With our flexible benefits scheme, you decide how to use part of your employment benefits. Purchase extra leave days or use your year-end bonus to buy a bicycle with tax benefits. You choose what suits you best.
- Warm welcome: We believe a good start is important. Thanks to our onboarding app, you’ll be well prepared even before your first working day. During the introduction day, you’ll get to know your colleagues and our organization.
- Changing allowance: If you are required to wear Radboudumc work clothing and change outside working hours, you will receive a changing allowance of €80 gross per month for a full-time position, provided this applies to your role.
- Salary increase: At our organization, your work is valued. Your salary will increase in line with the collective labor agreement in two steps: by 3.5% as of July 1, 2026, and an additional 3.5% as of May 1, 2027. This means you’ll see a solid increase in your salary within a short period of time.
- Work–life balance: We consider a healthy work–life balance essential. Through inspiring training sessions, mindfulness activities, and caregiver consultation hours, we support you in every phase of your life.
- Growth and development: Our online learning environment offers a wide range of training courses, e-learnings, and educational programs—from professional specialization to personal development. This allows you to keep growing and make the most of your talents.
Additional comments
- This position requires a Certificate of Conduct (VOG).
We are recruiting for this position ourselves. Unsolicited marketing is not appreciated, but do feel free to share the vacancy in your network!
Want to know more? We’re happy to provide more information!
Marleen Ansems
Marleen.Ansems@radboudumc.nl
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