PhD position available in Synthetic Chemistry for Development of Mitochondria Targeting and Genome Engineering.

About the Project

PIONEER (Programmable In-Organelle Nucleic-acid Entry, Expression and Retention) is an ambitious UK research consortium from Imperial College London, the University of Bristol, and the University of Glasgow, funded through the UK’s Advanced Research and Innovation Agency’s (ARIA) Precision Mitochondria programme, with a single bold goal: to build, from end to end, the ability to engineer the genome of mitochondria, the energy-producing compartments inside our cells.

The Opportunity: This is a rare chance to apply organic chemistry at the frontier of one of biology's great unsolved problems. You will design and synthesise novel small-molecule and ligand-based systems to ferry synthetic DNA across the double membrane of mitochondria.

The Science: For an organic chemist, this project offers something unusual: a molecule-to-organism design challenge where your ligand chemistry is the critical enabling step for the entire programme.

The Team: You will be supervised by Dr. Nazila Kamaly and co-supervised by Dr. Becky Greenaway and Professor Kim Jelf’s labs.

Who We're Looking For: We are seeking candidates holding, or about to hold, a Master’s degree in chemistry or a closely related field. A strong background in organic and/or medicinal chemistry is particularly desirable, as is experience in or enthusiasm for high-throughput or automated techniques.

How to Apply: Interested applicants are warmly encouraged to get in touch by email with a CV and a brief statement describing their interest in the field and any relevant research experience. Please contact Dr. Nazila Kamaly: nazila.kamaly@imperial.ac.uk

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