Post-Doctoral Associate in Retina Research

About the Job

Compensation Range: $62,232 – 75,564.00 annually; follows NIH stipend level by experience

Work Arrangement:
• The position is expected to work primarily on-site. Your work location will on the 3rd floor, Wallin Biomedical Biosciences.
• The Department retains the right to modify flexible work arrangement agreements on a temporary or permanent basis for any reason at any time.

All required qualifications must be documented on application materials.

Required Qualifications:
• PhD in Retinal Biology, Immunology, Molecular Biology, or a closely related biomedical field
• Experience with retinal immunopathology, photoreceptor biology, or RPE-related degenerative disease models
• Demonstrated expertise in retinal structure and function, including experience with gene expression analysis
• Hands-on experience with mouse models of inflammation, neurodegeneration, or retinal degeneration
• Strong written and verbal communication skills, demonstrated through peer-reviewed publications and conference presentations
• Demonstrated productivity through first-author publications

Preferred Qualifications:
• Skilled in molecular biology techniques including qPCR, cloning, western blotting, and CRISPR or shRNA-based gene knockdown
• Experience with RNA-seq or other transcriptomic analyses
• Experience in confocal imaging
• Experience in flow cytometry

Job Description:
This position seeks a highly motivated postdoctoral fellow to investigate how cell death sensors regulate immune responses, with an emerging interest in the retina. Building on our prior work (PMID: 35969037, PMID: 36662852) we aim to explore how recognition of photoreceptors outer segments or dying cells maintains homeostasis, results in inflammation and degeneration or induces repair in the retina. The project will integrate mouse models of genetically modified cell death sensors, retinal degeneration and inflammation.

Responsibilities:
• Design and conduct in vivo experiments using murine models to study immune regulation and retinal degeneration
• Conduct transcriptomic and pathway analyses (e.g., snRNAs-seq, RNA-seq) to uncover regulatory networks
• Use molecular and cellular tools (e.g., gene knockdown, qPCR) to dissect cell death sensing pathways
• Perform retinal functional assessments (e.g., ERG) and gene expression analysis in RPE and photoreceptors
• Perform high-dimensional flow cytometry for immune profiling
• Present findings at lab meetings and scientific conferences; contribute to collaborative research discussions
• Contribute to manuscript writing and data presentations for publication and conferences
• Mentor junior trainees and contribute to the lab’s collaborative and knowledge-sharing culture