Post-Doctoral Fellow – Forester Laboratory

Job Summary

This position reports directly to Craig Forester, MD, PhD, and will work within the Forester Lab, a component of the School of Medicine's Pediatric Hematology, Oncology and BMT. This position is involved in studies aimed at understanding the role of transcriptional gene regulation in hematopoietic stem cells and mutations found in pediatric bone marrow failure. Specifically, the Fellow will help investigate the role of Taspase1 mutations in early hematopoietic failure. The Fellow is expected to conduct research projects, to think independently, be highly motivated, design and carry out experiments, analyze data, and interpret and publish results.

Key Responsibilities

• Design and Performance of Research Experiments (75% of Time Spent)
• Mechanism based discovery of aberrant transcription in pluripotent tissues.
• Characterization of hematopoietic differentiation from iPSCs.
• Use of animal model systems to study hematopoietic engraftment.
• Engage in self-directed work with bioinformatic core to develop expertise in analysis of nascent transcription, CUT&Run and proteomics (if not already proficient)
• Analysis and Publication of Research Data (20% of Time Spent)
• Mentoring of students and technical staff (5% of Time Spent)
• Prepare data and manuscripts for publication
• Prepare grant proposals to obtain independent post-doctoral funding
• Actively participate in and present data at group meetings, journal clubs and conferences
• Work in conjunction with the PI and other lab staff to achieve programmatic goals, including student supervision
• Other duties as assigned

Work Location

Onsite – this role is expected to work onsite and is located on the Anschutz Medical Campus in Aurora, Colorado.

Qualifications

Minimum Qualifications

• A doctoral level degree (PhD, MD, MD/PhD) in immunology, stem cell biology, experimental hematology, molecular biology, cancer biology or equivalent from an accredited institution.
• At least one first-author publication in an internationally recognized, peer-reviewed journal.

Preferred Qualifications

• Graduate training in a biomedical laboratory setting, studying immunology, molecular biology, hematology and/or stem cell biology.
• Experience with the use of advanced flow cytometry equipment for analysis and sorting of cells, and development of multicolor antibody staining panels.
• Experience in mouse handling, husbandry and dissection.
• Experience in experimental hematology and molecular biology assays and techniques, including HSC isolation and analysis, and high-throughput sequencing.
• Experience in bioinformatic analysis of large datasets with proficiency in R or Python
• Candidates that have successfully obtained competitive, extramural funding during their doctoral studies are preferred.