Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation, and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to bone marrow failure or leukemia. Genome integrity plays a critical role in blood development and the prevention of leukemia and ageing. This postdoctoral fellow position will focus on studying the mechanisms that safeguard the genome during DNA replication and investigating how failures in these processes impact hematopoietic stem cell function, which leads to bone marrow failure and/or leukemia. CRISPR screens with our expert collaborators will delineate a new understanding of stem cell fitness upon replication stress and point to potentially druggable pathways for intervention in the treatment of diseases with stem cell dysregulation.
Our recent publications include: Cell Stem Cell, 28(7):1275-1290, 2021; Journal of Clinical Investigation 136(1): e191713, 2026; Blood 138(22):2244-2255, 2021; Blood 133(14): 1560-1571, Apr 2019; Nature communications 9(1): 3915, Sep 2018; Genes & development 31(10): 1007-1023, May 2017; You can find more of our recent publications and laboratory information in below website: https://www.med.upenn.edu/apps/faculty/index.php/g275/p8146029.
Qualifications
Candidates should have a Ph.D. or equivalent degree and experience with investigating biochemistry, cell biology, and molecular biology, as well as mouse models.
Highly motivated candidates with publication records are encouraged to apply.
Application Instructions
Please submit a brief statement of research experience and interest (cover letter), CV, and contact information for at least two references through interfolio. Applications will be reviewed on a rolling basis.
Questions or additional follow up can be sent to: Wei Tong, Ph.D - wei.tong@pennmedicine.upenn.edu Professor and Distinguished Chair in Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine (UPENN), Co-Director, Hematopoietic Stem Cell program, Institute for Regenerative Medicine at UPENN, Philadelphia, PA, USA
