"Postdoctoral position to study Polo kinase and centrosome abnormalities in cancer and other diseases"

Position Description

A postdoctoral fellowship is available to study the function of mammalian polo-like kinase 4 and 1 (Plk4 and Plk1), which play central roles in regulating various biological events, including centriole duplication, bipolar spindle formation, chromosome segregation, cell division, and proliferation. Dysregulation of Plk4/Plk1-dependent processes, by mutations in their associated cellular components or HIV accessory proteins, is tightly linked to the development of aneuploidy and cancer. During the past several years, we have been taking cell biological, biochemical, biophysical, and structural approaches (e.g., super-resolution imaging, single molecule tracking, in vitro reconstitution, X-ray crystallography, and cryo-EM) to delineate the molecular bases and structural rules governing the centrosomal architecture and function, the deregulation of which can lead to the development of various human diseases, including cancers, microcephaly, and AIDS. For additional information, please visit https://ccr.cancer.gov/staff-directory/kyung-s-lee.

Fellows who have an expertise in the field of cell biology, X-ray crystallography, or cryo-EM with a keen interest in learning about the organization and function of the centrosome and their relevance to pathophysiological disorders, such as cancer and AIDS, are encouraged to apply. Applicants should have a Ph.D. (or be expected to receive a Ph.D.) or M.D. equivalent at the time of joining the lab and have achieved the degree less than 3 years ago.

To apply, please send a CV and three names of references to Dr. Kyung Lee (kyunglee@mail.nih.gov). Starts at $67,200 for fellows with 0 yr postdoc training (+ annual raise) and complete health insurance.

Employer Name: National Cancer Institute, NIH.

Position Location: 9000 Rockville Pike, Bethesda, MD 20892, U.S.A.

Disciplines

Life Sciences, Biochemistry, Biophysics, Cell Biology, Computational Biology, Structural Biology

Position Type

Full Time, Postdoc, Postdoc Fellowship

Organization Type

Academia