Postdoctoral Research Assistant

The MRC PPU is one of the world’s most renowned centers for research on protein phosphorylation and ubiquitylation. We are recruiting for a driven individual to join us as a postdoctoral research assistant within the Dario Alessi lab, to study the molecular mechanisms of LRRK2 activation in health and disease. This project will use novel animal- and cellular models to robustly define key steps of LRRK2 membrane recruitment and kinase activation. This is a fixed-term appointment for 1 year with September 2026 as the start date.

Your priorities will include: Investigate basal and pathogenic mechanisms of LRRK2 kinase activity modulation across molecular-, cellular-, and organismal organization levels. Project development and implementation, including experimental design; identification and development of a broad range of techniques necessary to achieve the research. Working collaboratively and assisting with the training of PhD students and other lab members. Presenting scientific work at internal and external meetings. Contributing to the preparation of research for publication.

Who we’re looking for: Have obtained a PhD (or near completion) in a relevant discipline with outstanding academic track record with relevance to neuroscience. Have extensive knowledge of and experience in cell biology and biochemistry as well as excellent displayable laboratory skills in all the following techniques: Western blot, PCR, primary cell culture, genetic manipulation, and mass spectrometry. Have expertise in the design and execution of laboratory animal studies (mice), including tissues collection and processing, proven through prior track record. Have a strong ability to work independently but with excellent ability to work in a team, and an open and collaborative approach to science. Have excellent communication skills and knowledge of the English language are essential.