We want to help change that.
This Wellcome Trust-funded project aims to overcome a major bottleneck in the development of homing gene drive technology in Aedes aegypti: improving homing efficiency. Solving this challenge could enable the development of a new technology to control Aedes aegypti populations in a way that is effective, scalable, and affordable.
We are looking for a highly motivated individual with a strong can-do attitude who is excited by challenging science and motivated by the possibility of real-world impact. This is an opportunity to help build tools and systems that could contribute to the control of some of the world’s most important mosquito-borne diseases.
The nominal start date is October 2026, although this is negotiable. This is a full-time position.
Department
The successful candidate will join a large and highly collaborative research group of around 30 researchers working on different aspects of insect synthetic biology within the Department of Biology.
Role
The core aim of the project is to develop improved versions of homing gene drive systems in Aedes aegypti. This will involve designing, building, and testing new components, analysing their performance, troubleshooting challenges, and using the results to inform new designs.
A major part of the role will involve insect genetic studies, including the design and development of new transgenic and gene-edited mosquito strains, colony rearing and maintenance, phenotypic analysis, experimental design, and statistical analysis.
Additional responsibilities will include molecular biology work, such as assisting with the design and development of novel plasmids, preparing DNA for mosquito injections, molecular analysis of transgenic strains, and RNA-FISH. The successful candidate will also be expected to communicate progress and data clearly, contribute to manuscript preparation, and help train or supervise other staff and students where appropriate.
This is an ambitious and exploratory project, the role will offer significant opportunities to develop new skills, either in-house or through training in collaborators’ laboratories. This position would suit someone who is excited by difficult problems, enjoys building and testing new biological systems.
Skills, Experience & Qualification needed
- PhD in a relevant biological science, or equivalent
- Knowledge of relevant research techniques and methodologies.
- Good communication skills, ability to write up research work for publication in high profile journals
- Experience of working with insects, preferably molecular/genetic approaches
