Postdoctoral Research Fellow - Lyn Jones Lab

The Jones Lab is developing next-generation covalent chemical biology with the objective of expanding the druggable proteome. We seek a highly motivated individual to join our collaborative research efforts as a POSTDOCTORAL RESEARCH FELLOW who will work on chemical biology projects directed towards the development of novel therapeutic modalities.

We are based at Dana-Farber Cancer Institute in Longwood Center, and we have access to state-of-the-art facilities for chemistry, biophysics, biochemistry, structural biology, and mass spectrometry.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Responsibilities:

• Design and synthesize chemical probes for target validation and chemo proteomics studies
• Help develop and apply biochemical, biophysical, and metabolic stability assays
• Screen compounds; analyze and interpret data
• Apply data to the iterative design of optimized chemical probes suitable for cellular and in vivo pharmacological studies
• Maintain accurate lab records and documentation
• Contribute to publications and grant proposals.
• Stay current with scientific advances in the fields of chemical biology and medicinal chemistry, and apply emerging techniques and insights to their own research

Qualifications and Experience:

• PhD degree in chemical biology or a related discipline
• Strong background in synthetic organic chemistry, to enable delivery of chemical probes
• Expert in chemical biology techniques used to assess interactions between proteins and small molecules
• Experience in biochemical/biophysical assay development
• Excellent communication and presentation skills
• Evidence of consistent scientific innovation. Proven track record of publications in peer reviewed journals
• Able to work independently as well as in a collaborative team environment
• Excellent organizational and prioritization skills. Strong attention to detail
• Able to collect and analyze experimental data, prepare research publications, and communicate results