Research Assistant (BIRTH Study - Biochemistry)

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Job Description

The National University of Singapore invites applications for Research Assistant for “The BIRTH study – the Biomarker guided Intervention for Reducing Threat of High-risk preterm birth study” in the Department of Biochemistry, Yong Loo Lin School of Medicine. The Department undertakes excellence in research and scholarship through intimate support of our faculty and staff in the NUS Medicine Translational Research Programmes (TRPs). Our scientific strengths and leadership are evidenced by Biochemistry being the academic home of 4 TRP Directors, and by stellar research scholarship in cancer, cardiovascular disease, digital medicine, healthy longevity, human potential, infectious disease, immunology, precision medicine and synthetic biology. Appointments will be made on a 1-year contract basis in the first instance, with the possibility of extension.

Purpose of the post

We are seeking a skilled Research Assistant to support the development and validation of an advanced preterm birth (PTB) screening tool that integrates AI-based analysis of vaginal microbiome, miRNAs, maternal medical history, and demographic factors. The successful candidate will focus on sample preparation and analysis to identify microbial composition and activity associated with PTB using Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) and 16S rRNA sequencing. This is an excellent opportunity to work with cutting-edge DESI-MS technology, develop expertise in high-throughput Illumina sequencing, and contribute to impactful translational research. The successful candidate also has the prospect to receive overseas training in these techniques.

Main duties and responsibilities

This role is ideal for an individual passionate about maternal-fetal health and translational research, seeking to understand molecular and microbial factors driving preterm birth. The Research Assistant will:

1. Prepare and process biological samples for microbiome and biomarker analysis;
2. Conduct DESI-MS experiments to profile microbial composition and activity linked to PTB;
3. Perform 16S rRNA sequencing, including sample preparation, library construction, and quality control;
4. Maintain accurate laboratory records and ensure compliance with safety and quality standards;
5. Troubleshoot and optimize experimental protocols to improve throughput and data quality;
6. Collaborate with bioinformaticians, clinicians, and interdisciplinary researchers to achieve project goals;
7. Assist in preparation of reports, presentations, and scientific manuscripts;
8. Manage day-to-day project activities and support laboratory operations;
9. Perform other duties as assigned by the PI.

Qualifications

The applicant should have:

1. A Bachelor’s degree in Biology, Biochemistry, Molecular Biology, Microbiology, or related fields;
2. Hands-on experience with molecular biology techniques (DNA/RNA extraction, PCR, sequencing workflows);
3. Familiarity with mass spectrometry (DESI-MS preferred) or other analytical chemistry techniques; an opportunity to train overseas in the technique is available;
4. Knowledge of 16S rRNA sequencing and microbiome analysis is a plus;
5. Strong verbal and written communication skills, with ability to document research clearly;
6. Excellent

University-Level Unit: Yong Loo Lin School of Medicine

Faculty/Department-Level Unit: Biochemistry

Employee Category: Research Staff

Location: Kent Ridge Campus

Posting Start Date: 08/04/2026