Research Associate in Ophthalmology at University of Pennsylvania

Q: What qualifications are required for the Research Associate in Ophthalmology position?

Applicants must hold an M.D. and/or Ph.D. degree . Experience in iPSC lines , retinal ganglion cell differentiation , CRISPR technology , and omics studies (genome, transcriptome, proteome, metabolome) is essential for success in this role at the University of Pennsylvania . Explore research jobs or clinical research jobs for similar opportunities.

Q: What are the main responsibilities?

Key duties include conducting research on OPA3-mediated ophthalmic diseases , differentiating retinal ganglion cells and organoids from patient iPSC lines, performing structural, functional, metabolic studies , omics analyses for therapeutic efficacy, drug screening , applying CRISPR for disease models and gene therapy , developing LNP/AAV delivery platforms , writing peer-reviewed manuscripts , presenting at conferences, and preparing grant proposals . Check postdoc success tips .

Q: What is the duration and renewal policy?

The appointment is initially for 1 year , with continuation and renewal based on satisfactory performance and funding availability , limited to a maximum of 3 years . This is typical for academic support staff positions in medicine research .

Q: Is there teaching involved in this role?

No teaching load is mentioned; this is a pure research position focused on ophthalmology disease modeling and therapy development . Responsibilities emphasize lab work, data analysis, and publications rather than instruction. See faculty jobs for teaching roles.

Q: Where is the position located and what about diversity?

Located in Philadelphia, PA 19104, USA at the Perelman School of Medicine . The University of Pennsylvania is an EEO employer seeking candidates who embrace diversity ; minorities, women, individuals with disabilities, and protected veterans are encouraged to apply. Learn more via academic CV tips .

Research Associate in Ophthalmology

Description

The Department of Ophthalmology at the Perelman School of Medicine at the University of Pennsylvania seeks candidates for a Research Associate position in the Academic Support Staff. This appointment will be initially for one (1) year and continuation during that time period and renewal are based on satisfactory performance and availability of funding (limited to three (3) years). Applicants must have an M.D. and/or Ph.D degree.

Responsibilities may include conducting research on disease modeling and therapy development for OPA3-mediated ophthalmic diseases. Differentiate retinal ganglion cells and retinal organoids from knock-in and patient induced pluripotent stem cell (iPSC) lines and relevant isogenic control lines.

The successful applicant will have an opportunity to perform structural, functional, and metabolic studies on developed models. Perform genome, transcriptome, proteome, and metabolome studies to identify key outcome measures that can be used to asses therapeutic efficacy. Screen for commercially available as well as new drugs in diseased cell models. Apply CRISPR technology to both generate iPSC disease-models and develop gene therapy interventions. Develop appropriate delivery platform, LNP- or AAV-mediated. Write manuscripts to be published in peer-reviewed journals. Participate and present in scientific meetings and conferences, laboratory and department meetings. Prepare grant proposals.

We seek candidates who embrace and reflect diversity in the broadest sense. The University of Pennsylvania is an EOE. Minorities/women/individuals with disabilities/protected veterans are encouraged to apply.

Frequently Asked Questions

🎓What qualifications are required for the Research Associate in Ophthalmology position?

Applicants must hold an M.D. and/or Ph.D. degree. Experience in iPSC lines, retinal ganglion cell differentiation, CRISPR technology, and omics studies (genome, transcriptome, proteome, metabolome) is essential for success in this role at the University of Pennsylvania. Explore research jobs or clinical research jobs for similar opportunities.

🔬What are the main responsibilities?

Key duties include conducting research on OPA3-mediated ophthalmic diseases, differentiating retinal ganglion cells and organoids from patient iPSC lines, performing structural, functional, metabolic studies, omics analyses for therapeutic efficacy, drug screening, applying CRISPR for disease models and gene therapy, developing LNP/AAV delivery platforms, writing peer-reviewed manuscripts, presenting at conferences, and preparing grant proposals. Check postdoc success tips.

📅What is the duration and renewal policy?

The appointment is initially for 1 year, with continuation and renewal based on satisfactory performance and funding availability, limited to a maximum of 3 years. This is typical for academic support staff positions in medicine research.

❌Is there teaching involved in this role?

No teaching load is mentioned; this is a pure research position focused on ophthalmology disease modeling and therapy development. Responsibilities emphasize lab work, data analysis, and publications rather than instruction. See faculty jobs for teaching roles.

📍Where is the position located and what about diversity?

Located in Philadelphia, PA 19104, USA at the Perelman School of Medicine. The University of Pennsylvania is an EEO employer seeking candidates who embrace diversity; minorities, women, individuals with disabilities, and protected veterans are encouraged to apply. Learn more via academic CV tips.

University of Pennsylvania

Philadelphia, PA 19104, USA

"Research Associate in Ophthalmology"

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