Research Fellow (Cancer Science Institute)
Job Description
The Research Fellow will have opportunities to work with well-characterised clinical samples, state-of-the-art laboratory platforms, and an extensive network of local and international collaborators while contributing to high-impact publications and future clinical translation.
Key Responsibilities
- Design, plan, and execute independent research projects aligned with the laboratory's scientific objectives.
- Investigate mechanisms by which DNA damage and DNA repair defects influence innate and adaptive immune responses in cancer.
- Study immunogenic cell death, cytosolic nucleic acid sensing pathways, and tumour immune microenvironment modulation following genotoxic chemotherapy.
- Develop and optimise molecular and cellular assays related to DNA repair, immune activation, and cancer biology.
- Perform and interpret experiments using cell line models of epithelial and lymphoid malignancies.
- Apply quantitative microscopy and histopathological imaging techniques to investigate immune modulation pathways in human tumour samples.
- Analyse and interpret complex experimental datasets using appropriate statistical and computational approaches.
- Collaborate with clinicians and translational researchers to analyse patient-derived clinical specimens and develop clinically relevant biomarkers.
- Contribute to the design and evaluation of novel chemotherapy-immunotherapy combination strategies.
- Prepare manuscripts for publication in peer-reviewed journals and present findings at scientific conferences.
- Assist in preparing research grant applications and progress reports.
- Mentor graduate students, research assistants, and junior laboratory members where appropriate.
- Contribute to laboratory management, protocol development, and maintenance of high standards of scientific integrity and research compliance.
- Foster a collaborative, respectful, and inclusive research culture.
Qualifications
- PhD in Cancer Biology, Immunology, Molecular Biology, Cell Biology, Biomedical Sciences, Genetics, or a related discipline.
- Strong publication record in peer-reviewed scientific journals.
- Demonstrated expertise in one or more of the following: DNA damage response and DNA repair biology, Cancer immunology, Molecular and cellular biology, Immunofluorescence and quantitative microscopy, Flow cytometry, CRISPR/Cas9 genome editing, Genomic and transcriptomic analyses, Cancer cell culture and functional assays
- Experience working with animal models and/or human clinical specimens would be advantageous.
- Familiarity with bioinformatics or computational analysis of biological datasets is desirable.
- Excellent scientific writing, presentation, and communication skills.
- Ability to work both independently and collaboratively within multidisciplinary teams.
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