"Staff Scientist"

STAFF SCIENTIST IN ADVANCED MULTINUCLEAR MULTI-DIMENSIONAL PROTEIN NMR DEER EPR SPECTROSCOPY OF MEMBRANE PROTEINS

DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSITTUTES OF HEALTH, NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES, BETHESDA, MARYLAND

The Section of Molecular and Structural Biophysics in the Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), at the National Institutes of Health (NIH), is searching for a Staff Scientist who will study the effect of membrane environment on the function of G-protein coupled receptors (GPCR) using solution NMR and double electron-electron resonance EPR spectroscopy. The NIH is the world's largest medical research facility, and the Laboratory of Chemical Physics is a collaborative and exciting research environment studying experimental, theoretical, and computational problems in the structure, dynamics, and function of biological macromolecules and their relevance to human disease, including Alzheimer’s, Parkinson’s, and sickle cell diseases.

Salary will be commensurate with experience ranging from $80,354 - $169,093. A full civil service package of benefits may be available including retirement, health, life, and long-term care insurances, leave and Thrift Savings Plan.

Applicants must hold a Doctor Philosophy (Ph.D.) The ideal candidate will have a minimum of 5 years of postdoctoral biomedical/biophysics research experience. A strong publication record using the skills described below is required. Candidates must have extensive demonstrated experience with expression and purification of membrane proteins for structural studies, reconstitution of GPCRs in both lipid micelles and nanodiscs, and extensive demonstrated experience in both multidimensional triple resonance NMR spectroscopy and DEER EPR spectroscopy, molecular biology and protein engineering. Expertise with both Bruker NMR and EPR equipment is required.

Appointees may be a US citizen, Legal Permanent Resident or non-US citizen who are eligible for a valid work authorization

Interested candidates should submit a current CV with bibliography, a 1 page research statement (including your background, your interests in the position and how it fits into your career plans) and list of 3 references to Dr. Marius Clore at mariusc@mail.nih.gov. Applications must be received by March 10, 2026.

All employees are subject to background investigation. DHHS and NIH are Equal Opportunity Employers.