Defective DNA repair is a major driver of genetic instability and cancer development. This PhD project, based in Professor Stewart’s laboratory, will investigate how cells detect and repair DNA damage, and how defects in these processes give rise to human disease. By studying rare inherited disorders, the project aims to generate fundamental insights into the DNA damage response and its role in conditions such as neurodegeneration, developmental abnormalities, immune dysfunction, infertility,…

Defective DNA repair is a major driver of genetic instability and cancer development. This PhD project, based in Professor Stewart’s laboratory, will investigate how cells detect and repair DNA damage, and how defects in these processes give rise to human disease. By studying rare inherited disorders, the project aims to generate fundamental insights into the DNA damage response and its role in conditions such as neurodegeneration, developmental abnormalities, immune dysfunction, infertility,…