Acute myeloid leukaemia (AML) is an aggressive, heterogeneous cancer marked by clonal expansion of primitive haematopoietic stem cells in the bone marrow.

Alternative splicing, the generation of multiple mRNA isoforms from a single gene, is associated with AML progression and therapy resistance. This project will utilise multiple genome-wide sequencing techniques, knock-out/knock-in mouse models, in vitro and in vivo models of leukaemia to investigate the role of alternative splicing in leukemogenesis and evaluate novel therapeutic strategies for the treatment of AML.