University Assistant Predoctoral in Environmental Toxicology of Tire Antioxidants

Your personal sphere of influence:

You will join the Department of Environmental Geosciences (EDGE) at the Centre for Microbiology and Environmental Systems Science (CeMESS) to investigate p phenylenediamine (PPD) tire antioxidants and their quinone transformation products (PPD Qs).

The project you will be working on studies tire antioxidant chemicals (PPDs) and their quinone products (PPD‑Qs) released by tire and road wear, and investigates how their properties affect transport across cell membranes, binding to blood proteins, and effects on human cells.

Your future tasks:

• Plan and execute experiments to quantify passive transport, membrane partitioning, and plasma protein binding for selected PPDs and PPD Qs, ensuring appropriate test conditions and quality control.
• Generate concentration–response data in intestinal and lung cell models to compare toxicity across ingestion and inhalation relevant tissues.
• Perform mechanistic studies to differentiate baseline toxicity from specific mode of toxic action.
• Analyze how lipophilicity and electrophilicity relate to transport, binding, and cellular outcomes.
• Manage data analysis and documentation; contribute to manuscripts and presentations.
• Progress your dissertation; contribute to teaching and administrative tasks; supervise undergraduate/master’s students as appropriate.